Definition
To deliberately make something refuse to dissolve, which is the chemical equivalent of teaching a substance to be stubbornly independent. It's the opposite of solubilize, used when you want compounds to stay separate rather than mix together. Scientists do this when they need materials to resist dissolving in specific environments, like medications that shouldn't break down until they reach the right part of your digestive system.
Example Usage
The coating process insolubilized the active ingredient, ensuring it would survive the acidic environment of the stomach.
Source: Chemistry and pharmaceutical terminology
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